
v) Risk adjustment is under review currently and will be revised by the end of the year –
Coordinating Center will add new methodology to spec once available
(1) Michael Mathis: Recommends threshold be re-evaluated once risk adjustment model is
updated
vi) KDIGO AKI definition used for this measure – still relevant in 2020
vii) Several references recommended to be added to the measure spec:
(1) Khwaja A: KDIGO Clinical Practice Guidelines for Acute Kidney Injury 2012; 120:pp c179–
84
(2) Levey AS, Stevens LA, Schmid CH, Zhang YL, Castro AF 3rd, Feldman HI, Kusek JW, Eggers
P, Van Lente F, Greene T, Coresh J, CKD-EPI (Chronic Kidney Disease Epidemiology
Collaboration): A new equation to estimate glomerular filtration rate. Ann Intern Med
2009; 150:604–12
(3) Gumbert SD, Kork F, Jackson ML, Vanga N, Ghebremichael SJ, Wang CY, Eltzschig HK:
Perioperative Acute Kidney Injury. Anesthesiology 2020; 132:180–204
(4) Turan A, Cohen B, Adegboye J, Makarova N, Liu L, Mascha EJ, Qiu Y, Irefin S, Wakefield
BJ, Ruetzler K, Sessler DI: Mild Acute Kidney Injury after Noncardiac Surgery Is
Associated with Long-term Renal Dysfunction: A Retrospective Cohort Study.
Anesthesiology 2020; 132:1053–61
(5) Meersch M, Schmidt C, Hoffmeier A, Van Aken H, Wempe C, Gerss J, Zarbock A:
Prevention of cardiac surgery-associated AKI by implementing the KDIGO guidelines in
high risk patients identified by biomarkers: the PrevAKI randomized controlled trial
2017; 43:pp 1551–61
(6) Futier E, Lefrant J-Y, Guinot P-G, Godet T, Lorne E, Cuvillon P, Bertran S, Leone M,
Pastene B, Piriou V, Molliex S, Albanese J, Julia J-M, Tavernier B, Imhoff E, Bazin J-E,
Constantin J-M, Pereira B, Jaber S, INPRESS Study Group: Effect of Individualized vs
Standard Blood Pressure Management Strategies on Postoperative Organ Dysfunction
Among High-Risk Patients Undergoing Major Surgery: A Randomized Clinical Trial. JAMA
2017; 318:1346–57
(7) Mathis MR, Naik BI, Freundlich RE, Shanks AM, Heung M, Kim M, Burns ML, Colquhoun
DA, Rangrass G, Janda A, Engoren MC, Saager L, Tremper KK, Kheterpal S, Aziz MF,
Coffman T, Durieux ME, Levy WJ, Schonberger RB, Soto R, Wilczak J, Berman MF, Berris
J, Biggs DA, Coles P, Craft RM, Cummings KC, Ellis TA 2nd, Fleishut PM, Helsten DL, et al.:
Preoperative Risk and the Association between Hypotension and Postoperative Acute
Kidney Injury. Anesthesiology 2020; 132:461–75
c) Reviewers recommendation (Mathis:
i) Recommendation: Continue the measure as-is (adding references and risk adjustment
methodology once updated)
(1) KDIGO still is most widely accepted way to define AKI
(2) Current evidence still suggests perioperative AKI is associated with long-term health
risks, hospital costs, and mortality
d) AKI 01 Measure Discussion:
i) Eric Davies (Henry Ford Allegiance): This measure relies on labs being obtained reliably after
surgery to assess for AKI. I think we need a measure that simply identifies the percentage of
cases that had a postop creatinine measured